Postfix through 3.8.5 allows SMTP smuggling unless configured with smtpd_data_restrictions=reject_unauth_pipelining and smtpd_discard_ehlo_keywords=chunking (or certain other options that exist in recent versions). Remote attackers can use a published exploitation technique to inject e-mail messages with a spoofed MAIL FROM address, allowing bypass of an SPF protection mechanism. This occurs because Postfix supports <LF>.<CR><LF> but some other popular e-mail servers do not. To prevent attack variants (by always disallowing <LF> without <CR>), a different solution is required, such as the smtpd_forbid_bare_newline=yes option with a Postfix minimum version of 3.5.23, 3.6.13, 3.7.9, 3.8.4, or 3.9.

A certain Postfix 2.10.1-7 package could allow an attacker to send an email from an arbitrary-looking sender via a homoglyph attack, as demonstrated by the similarity of \xce\xbf to the 'o' character. This is potentially relevant when the /etc/postfix/sender_login feature is used, because a spoofed outbound message that uses a configured sender address is blocked with a "Sender address rejected: not logged in" error message, but a spoofed outbound message that uses a homoglyph of a configured sender address is not blocked. NOTE: some third parties argue that any missed blocking of spoofed outbound messages - except for exact matches to a sender address in the /etc/postfix/sender_login file - is outside the design goals of Postfix and thus cannot be considered a Postfix vulnerability

In postfix-mta-sts-resolver before 0.5.1, All users can receive incorrect response from daemon under rare conditions, rendering downgrade of effective STS policy.

PostfixAdmin 2.3.4 has multiple XSS vulnerabilities

Postfix before 2.11.10, 3.0.x before 3.0.10, 3.1.x before 3.1.6, and 3.2.x before 3.2.2 might allow local users to gain privileges by leveraging undocumented functionality in Berkeley DB 2.x and later, related to reading settings from DB_CONFIG in the current directory.

The AliasHandler component in PostfixAdmin before 3.0.2 allows remote authenticated domain admins to delete protected aliases via the delete parameter to delete.php, involving a missing permission check.

Multiple SQL injection vulnerabilities in Postfix Admin (aka postfixadmin) before 2.3.5 allow remote authenticated users to execute arbitrary SQL commands via (1) the pw parameter to the pacrypt function, when mysql_encrypt is configured, or (2) unspecified vectors that are used in backup files generated by backup.php.

SQL injection vulnerability in the gen_show_status function in functions.inc.php in Postfix Admin (aka postfixadmin) before 2.3.7 allows remote authenticated users to execute arbitrary SQL commands via a new alias.

The SMTP server in Postfix before 2.5.13, 2.6.x before 2.6.10, 2.7.x before 2.7.4, and 2.8.x before 2.8.3, when certain Cyrus SASL authentication methods are enabled, does not create a new server handle after client authentication fails, which allows remote attackers to cause a denial of service (heap memory corruption and daemon crash) or possibly execute arbitrary code via an invalid AUTH command with one method followed by an AUTH command with a different method.

The STARTTLS implementation in Postfix 2.4.x before 2.4.16, 2.5.x before 2.5.12, 2.6.x before 2.6.9, and 2.7.x before 2.7.3 does not properly restrict I/O buffering, which allows man-in-the-middle attackers to insert commands into encrypted SMTP sessions by sending a cleartext command that is processed after TLS is in place, related to a "plaintext command injection" attack.