In Puma (RubyGem) before 4.3.2 and before 3.12.3, if an application using Puma allows untrusted input in a response header, an attacker can use newline characters (i.e. `CR`, `LF` or`/r`, `/n`) to end the header and inject malicious content, such as additional headers or an entirely new response body. This vulnerability is known as HTTP Response Splitting. While not an attack in itself, response splitting is a vector for several other attacks, such as cross-site scripting (XSS). This is related to CVE-2019-16254, which fixed this vulnerability for the WEBrick Ruby web server. This has been fixed in versions 4.3.2 and 3.12.3 by checking all headers for line endings and rejecting headers with those characters.

In Puma before versions 3.12.2 and 4.3.1, a poorly-behaved client could use keepalive requests to monopolize Puma's reactor and create a denial of service attack. If more keepalive connections to Puma are opened than there are threads available, additional connections will wait permanently if the attacker sends requests frequently enough. This vulnerability is patched in Puma 4.3.1 and 3.12.2.

The PUMA PUMATRAC app 3.0.2 for iOS does not verify X.509 certificates from SSL servers, which allows man-in-the-middle attackers to spoof servers and obtain sensitive information via a crafted certificate.