index.php in Francisco Burzi PHP-Nuke 5.3.1 and earlier, and possibly other versions before 5.5, allows remote attackers to execute arbitrary PHP code by specifying a URL to the malicious code in the file parameter.

Cross-site scripting (XSS) vulnerability in PHP-Nuke 5.3.1 and earlier allows remote attackers to inject arbitrary web script or HTML via the (1) uname parameter in user.php, (2) ttitle, letter and file parameters in modules.php, (3) subject, story and storyext parameters in submit.php, (4) upload parameter in admin.php and (5) fname parameter in friend.php.

PHP-Nuke 5.x allows remote attackers to perform arbitrary SQL operations by modifying the "prefix" variable when calling any scripts that do not already define the prefix variable (e.g., by including mainfile.php), such as article.php.